No Statistics Without Clinical Evaluation

Statistics without DATA _NULLS_

Analysts attracted to SAS for its statistical capabilities no longer have to settle for its clumsy publishing capabilities. Instead, they can take advantage of the Output Delivery System (ODS) in version 7.0, SAS’s data warehouse and data processing capabilities, and a new open-source, non-proprietary software technology, and literally never use a DATA _NULL_, PROC REPORT, or PROC TABULATE agai...

No surgical innovation without evaluation: the IDEAL recommendations.

Surgery and other invasive therapies are complex interventions, the assessment of which is challenged by factors that depend on operator, team, and setting, such as learning curves, quality variations, and perception of equipoise. We propose recommendations for the assessment of surgery based on a five-stage description of the surgical development process. We also encourage the widespread use o...

Evaluation of test statistics in split-mouth clinical trials.

This study was undertaken to examine the appropriateness of test statistics used for split-mouth clinical trials. Twenty-two published trials were reviewed and the primary test statistics were labeled as appropriate, inappropriate, or absent. Only 5 of the 22 trials reported an appropriate test statistics. Of the remaining 17 (rials, 12 used an inappropriate lest statistics, and 5 did not repor...

Using Order Statistics in Clinical Trial Safety Evaluation

Analyses of data on safety/tolerability from clinical drug trials seek primarily to provide a reliable description of potential tolerability or toxicity problems that may occur in clinical practice. In addition, formal tests of the hypothesis that the experimental and control drugs present equal risk of adverse event (AE) occurrence often are carried out for each AE that occurs with some minimu...

Can Statistics Do without Artefacts?